![]() ![]() Proteoliposomal tmSCF preferentially acted on endothelial cells to induce angiogenesis while tmSCF nanodiscs had greater activity in inducing stem cell mobilization and recruitment to the site of injury. Mouse models of anaphylaxis and ischemia revealed the tmSCF-based therapies did not activate mast cells and improved the revascularization in the ischemic hind limb. We created novel therapeutics using tmSCF embedded in proteoliposomes or lipid nanodiscs. Transmembrane SCF (tmSCF) has differential activity from soluble SCF and has not been explored as a therapeutic agent. While clinical treatments using SCF would be highly beneficial, these have been limited by toxicity related to mast cell activation. Stem cell factor (SCF) is a cytokine that regulates hematopoiesis and other biological processes. Vice Provost for Undergraduate Education. ![]() Office of Vice President for Business Affairs and Chief Financial Officer.Office of VP for University Human Resources.Stanford Woods Institute for the Environment.Stanford Institute for Economic Policy Research (SIEPR).Institute for Stem Cell Biology and Regenerative Medicine. ![]()
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